I had a chance to get to "work" (aka get it installed on my system) with it for quite some time now, because my company is Microsoft Gold partner. Be we don't use it in a production environment and some of us are just fooling around with it.
Well, the major change is, that the IDE is WPF based. With the 1st test releases, this had a huge performance impact and IMHO it looked sort of strange. But the speed is now "acceptable". But I wonder how fast it will in Monday's version.
F# is another .Net language you can use now. It is .Net/IL based.
I know there are some things broken in WPF, which worked in 3.5. I have submitted some reports and had some e-mail exchanges... I just hope they fixed it in this release.
.Net 4 is quite a nice environment. There are some very interesting improvements to LINQ (aka PLINQ).
Somehow I missed all the new features they promised to add for C++... or maybe I just spent too less time to search for them.
Oh, I hate the new help system... I just hope they will release the "old" local viewer.
I didn't check Azure, Silverlight, XNA, or the other millions of new stuff they added... I didn't have too much time to play with it at the offce and in my spare time I prefer to look at other things like
Erlang/OTP.