say your motherboard has 2 slots for memory and for an example you are running pc 2700 512 ddr ram
you can add in to slot 2 only!!! pc 3200 512 ddr ram when you install and reboot check your bios and it should downgrade the pc3200 to pc2700.
does it work yes it does
the correct memory MUST be in slot 1 obviously if you have 4 slots slot 1 + 3 should be the correct memory for your machine